DIRECTING THE IMMUNE RESPONSE THROUGH DESIGNED NANOMATERIALS

what is Dirnano

DIRNANO comprises several European researchers, professionals, entrepreneurs, edutainers and business trainers

• Scientists have complementary expertise;
• Integrated team will ensure design of nanoparticles core or coating and derivatization;
• R&D companies will contribute to searching for new innovative coating agents, chance to develop optimal stealth or immune-targeted nanoparticles and develop new immunological tools;
• Partner Organizations will support workshops and classes.

PURPOSE OF THE PROJECT

Dirnano provides a highly integrated and interdisciplinary training of next-generation Early Stage Researchers (ESRs) at the interface of nanopharmaceutical bioengineering and its translation on preclinical and human immunology.

Dirnano will develop biocompatible nanopharmaceuticals with either “super”-stealth or immune- specific behavior for cancer immunotherapy and vaccination by mapping nanoparticle-immune interactions through two core approaches:

1. inception of novel surface engineering approaches, based on new organic polymers, zwitterionic lipids and conjugation chemistry strategies,
2. engineering of host or microbial-derived modulators of innate immunity (e.g. complement system).